Conformational Flexibility of Human Casein Kinase Catalytic Subunit Explored by Metadynamics
نویسندگان
چکیده
منابع مشابه
Conformational flexibility of human casein kinase catalytic subunit explored by metadynamics.
Casein kinase CK2 is an essential enzyme in higher organisms, catalyzing the transfer of the γ phosphate from ATP to serine and threonine residues on protein substrates. In a number of animal tumors, CK2 activity has been shown to escape normal cellular control, making it a potential target for cancer therapy. Several crystal structures of human CK2 have been published with different conformati...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.01.031